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A total of thirteen mutations were newly identified for single copy genes in this study.
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Resorting to music theory, genetic operators (i.e., crossover and mutation) are newly designed to improve search capability in the multi-objective fitness space of music composition.
Some of the newly discovered mutations were new to prostate cancer but have been seen in other forms of cancer where drugs are already in use.
As expected, eleven out of the twenty-four mutations found were newly discovered mutations, never reported before.
Furthermore, massively parallel sequencing also validated the four additional mutations that were newly detected by sensitive pyrosequencing: EGFR exon 19 deletions in sample 05 and 27, the G12A mutation of KRAS in sample 11 and the T790M mutation of EGFR in sample 10 (Table 1).
We analyzed the medical records of 39 patients with EGFR mutation-positive NSCLC who were newly diagnosed at our institute between January 2003 and August 2010, underwent TKI therapy, and died before February 2012.
According to the genome sequence analysis performed previously [ 5], a comparable number of genome mutations responsible for transcriptional regulation were newly accumulated in each strain (summarized in Additional file 1: Table S1).
They were newly married.
My wife and I were newly married.
All were newly diagnosed.
De-novo mutations were defined as newly occurring changes (as compared to the first sequence time-point) within known epitopes or at HLA-association sites relevant for the host's HLA.
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