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Simultaneous exon 12 mutations were never found.
Similarly, 40% of HNPCC cases display KRAS mutations and BRAF mutations were never found (4, 5).
Sixty-two of the 76 female patients with mutations were never smokers, in which 40 patients (65%) had an L858R mutation.
On the other hand, KRAS mutations were never detected in S-MSI, while they were identified in 43 % of LS-MSI, in 30%% of S-MSS, and in 30%% of EO-MSS CRC (p = 0.0012; Table 2 and Fig. 5a).
Although p53 mutations were never found to occur in HSC or other types of nontransformed cells, these findings suggest a noncell autonomous function of p53 in the TME that can be manifested upon downregulation of p53 expression on account of gene methylation or other mechanisms.
Finally, our data support that complementary deficits in RPGR1 19 or RPGRORF15 caused by mutations in their shared RHD domain may impair cumulatively the subcellular targeting of RPGRIP1α1 and underlie the pathogenesis of XlRP3 even though human mutations were never found in the unique C-terminal domain of RPGR1 19.
Similar(53)
Mutations are never beneficial.
D R).555 Mutations are never beneficial.
0.408 Mutations are never beneficial.H 0.356 Evolutionary knowledge 0.72 5.02 0.86 In most populations, more offspring are born than can survive.
Homozygosity or compound heterozygosity for two nonsense mutations was never found.
Though the authors noted that onset in GNAL mutations was never brachial, this may just be a chance finding given the small number of cases identified so far, rather than a true distinguishing factor.
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