Sentence examples for mutations were necessary from inspiring English sources

However, both mutations were necessary for the full das effect in vivo.

Because Kcv* bore eight amino acid changes, we used a PCR backcrossing procedure [29] as a way to dilute the mutations into a wild-type background to address which mutations were necessary for the phenotype and probe whether multiple changes working in concert were required for the apparent blocker resistance.

This reductionist thinking led the initial theories on carcinogenesis to be centered on how many "hits" or genetic mutations were necessary for a tumor to develop.

Nonetheless, even in these examples, in vitro assays that tested the functional consequences of the mutations were necessary for the researchers to present compelling arguments.

To ask which mutations were necessary for the oscillator we selected for "sub-traits" of the oscillator from a pool of spores containing different combinations of the eight E6-1 mutandons askedsked which mutation segregated with each sub-trait.

Molecular analysis of clinical material then confirmed that both, clonal expansions and stepwise accumulation of specific mutations were necessary for carcinogenesis in most human cancers (Fearon and Vogelstein, 1990).

It may be more relevant to evaluate the potential contribution of mutator mutations to the efficiency of tumorigenesis, as opposed to whether mutator mutations are necessary to explain a rate of cancer lineage birth rate equal to that of clinically observed cancer incidence.

(In Darwin's world, of course, a certain number of those mutations are necessary).

How is change possible where multiple mutations are necessary but intermediate steps have no apparent advantage?

Additional biological and pathophysiological data associated with the identified mutations are necessary for more optimal prosecution of these drug discovery programs.

Some have asserted that these recommendations represent unwarranted censorship of scientific research and that the sharing of the results, particularly the specific viral mutations, is necessary to protect global public health.