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The verified tolerance-conferring effect of the UBP7 mutation to which they were initially linked, and which gained in frequency over population evolution, suggests that these linked mutations were merely carried through to strain R57 from UV mutagenesis.
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In particular, it has not been established whether somatic mutations of mtDNA are involved in molecular mechanisms of tumour development or whether these mutations are merely associated with the tumourigenic process but lack a causative role.
Any given mutation is merely a chance error in the genetic system, and as such, its likelihood of occurrence is not influenced by whether it will turn out to be detrimental, beneficial, or (most commonly) neutral.
Other than that, all mutations were found merely by the Roche assay.
The mismatch-specific endonuclease method for beta-thalassemia mutations detection is merely as a model for other (large) disease genes for which large scale, high-throughput mutation scanning.
Others were merely cryptic.
They were "merely" hungry.
Since MSI tumors are prone to mutation throughout the genome, the question arises of whether the NKD1 mutations drive tumor progression or are merely "bystander" mutations.
The conventional mutation operator randomly alters the value of the genes according to a small probability of mutation; thus, it is merely a random walk and does not guarantee a positive direction toward the optimal solution.
While the hypothesis that PINK1 is a pro-fusion protein is exciting, it remains possible that the effects of PINK1 deficiency (or expression of the PINK1 protein carrying a PD mutation) on mitochondrial morphology are merely downstream consequences of a direct action on an entirely distinct process such as ROS production, low ΔΨm and calcium flux (see 'PINK1 in calcium signalling' section).
As in all such screens, a major issue is whether the mutations observed are selected for in the cancer or are merely accidental 'passenger' mutations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com