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The results confirmed that the fitness consequences of the accumulated mutations were lower in the viruses historically evolving at low coinfection, meaning that these viruses were indeed more robust.
The response rates for patients with V600K mutations were lower.
As expected, due to strong functional constraint, the levels of nucleotide variation in exon region (150 variable characters, 9 transition mutations, and 3 transversion mutations) were lower than those in intron region (407 variable characters, 25 transition mutations, and 19 transversion mutations).
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From these crosses we find the ratio of non-synonymous to synonymous mutations is lower in duplicated genes, which suggests that they are under greater purifying selection.
The number of stop mutations was lower than the CODDLE predicted proportions.
It is clear from our study that the sensitivity to EndoA-BAR mutations is lower in larvae than in adults.
Overall, substitution scores of Mendelian disease and cancer somatic mutations are lower than those of polymorphic variants, suggesting deleterious and harmful effects when they occur.
As expected, the distribution of mutations reflected patterns previously observed in human tumors, although the frequency of TS mutations was lower (reflective of the reduced coverage of such mutations by OncoMap).
There was a marked variation in mutation frequency both within the patient group (0.02%–0.70%) and controls (0.00%–2.21%), although, in general, the rate of mutations was lower in the NBS patients (average 0.45% vs. 1.48% in controls).
The found frequency of K-ras mutations was lower than expected.
In Brazil, the prevalence of HFE mutations is lower than in populations of northern Europe.
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