Sentence examples for mutations were last from inspiring English sources

In 15 of the 20 patients whose mutations became undetectable by Sanger-sequencing after changing therapy, the mutations have not been detected by Sanger-sequencing again with 0.1 7.5 years of follow-up since the mutations were last detected (median 1.7 years; Table 1, patients 1 15).

Proatherogenic mutations were C5178A and C3256T; antiatherogenic mutation was G12315A.

All patients were infected with genotype C viruses, and the most common mutations were G1613A and C1653T.

These new mutations were c.1174delTG (in exon 10), c.710delC (exon 6), c.406delTT (exon 5) and c.393insTCAGC (exon 5).

The allele frequency for mild mutations was 0.059.

The allele frequency for severe mutations was 0.007.

The overall average ratio of non-synonymous and synonymous mutations was 0.471 (N/S) and that of RNA and synonymous was 0.324 (RI/S).

The average number of mutations was 233.1, representing an overall mutation rate of 4.72 Mb−1.

The number of inferred synonymous mutations is 571.1 and 484.9, respectively.

- Mean age of onset in patients with protein-truncating mutations was 9.9 years while that in patients with missense mutations was 10.46 years.

The frequency of KRAS exon 2 mutations is approximately 35 40% in colorectal cancer patients, and the frequency of other RAS mutations is 10 15%; the same trend exists in Europe and the USA, and Japan (Table 4).