Sentence examples for mutations were instead from inspiring English sources

In 3 invasive cases and 15 ductal carcinoma in situ/proliferative lesions, PIK3CA hotspot mutations were, instead, tested by direct sequencing.

However, our study did not detect equivalent mutations on the SRV proviral sequences of Vero JCRB0111 cells; however, other notable mutations were instead detected (Supplementary Table S5).

In the remaining 16 genes (∼36%), mutations were instead associated with a specific subgroup, corresponding to just 33 of the identified mutations (∼8%) and suggesting that subgroup specificity might be due to their low frequency.

Three of the described mutations were instead point mutations that did not compromise the reading frame of the gene and were, thus, compatible with the expression of the full length PMCA2 w/a variant of the pump; they all affected residues that are highly conserved in all PMCA isoforms across species and in other P-type pumps [ 69, 74, 75].

It is thought that the most likely explanation for this is that males with germline mutations are nonviable and that postzygotic mutations are instead responsible for the condition in males [ 44 ▪].

The mutation is instead located in the GTPase domain located at the C-terminus of McrB, in a region conserved between several McrB sequences [ 67].

Conversely, the BRCA2 c.3950_3952delTAGinsAT, which was previously reported as a founder mutation, was instead running in families belonging to a single extended pedigree confined to a small village of the central part of Sardinia [ 19].

TERT mutations are mutually exclusive with ATRX (alpha thalassemia mental retardation syndrome X linked) mutations, which are instead seen in the majority of WHO grade II-III astrocytomas and secondary glioblastomas.

Surprisingly, the researchers reported that the mutations, which stemmed from the sperm, were instead corrected using the healthy version of MYBPC3 found in the egg genomes.

Thus, somatic evolution in HSC pools and consequently hematopoietic malignancies are not rate-limited by the occurrence of oncogenic mutations and are instead driven by altered positive selection in aging tissues for previously generated genetic and phenotypic cell diversity.

No deleterious mutations were found, but instead many variants (missense, silent, intronic and in the promoter), already reported in the databases, were recorded.