Sentence examples for mutations were initially from inspiring English sources
Four other eat-6 mutations were initially isolated for feeble contractions and delayed relaxations of the pharyngeal muscles [9], and subsequently shown to affect the membrane potential of these cells [10].
Instead, all of these mutations were initially discovered because they affected other biological phenomenon, such as suppression of the zeste phenotype [Su z 2], dosage compensation (msl-3), or alteration of homeotic gene expression (Psc).
The two mutations were initially identified as de novo mutations.
Mutations were initially discovered in DKC1, located on the X chromosome (Heiss et al, 1998).
In some amplicons, certain mutations were initially not detected by the HRM assays.
FBXW7 mutations were initially identified by Spruck et al in ovarian and breast cancer cell lines.
8, 15– 20 The validity of the pyrosequencing method for detecting KRAS and BRAF mutations was initially demonstrated using colon cancer cell lines and colon cancer tissues harboring KRAS and BRAF mutations.
Simultaneous and homozygous deletion of the mouse Brca1, Brca2 and p53 genes leads to immediate cellular transformation, whereas human germline BRCA1 and BRCA2 mutations are initially heterozygous [ 41, 42].
The presence of kinase domain EGFR mutations was initially described in patients responding to gefitinib and erlotinib[ 9 11 ] and is now recognised as an important predictor of response, albeit without sufficient sensitivity or specificity to be used alone as a selection criterion for second line treatment.
Mutants dmr1- 1, dmr1- 2, dmr5 and dmr6 (all of which also carry the eds1- 2 mutation) were initially investigated; dmr3 and dmr4 have pleiotropic dwarf phenotypes which affect floral morphology and were therefore unsuitable for inclusion in this study.
Mice carrying the classic Crouzon syndrome associated Fgfr2C342Y mutation were initially reported to have characteristics similar to those of Crouzon syndrome patients including a dome-shaped skull, wide set and proptotic eyes, premature fusion of cranial sutures, and a shortened maxilla [ 32].
