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Mutational frequency and type of somatic point mutations were highly variable among the different MPNSTs modeled, but very consistent when comparing primary tumors with matched orthoxenografts generated.
Figure 3: Pathogenic mutations were highly enriched in Tibetan highlanders.
The explanation of this phenomenon is that dark moths, which originally were chance mutations, were highly visible to predators when resting on lichen-covered trees during the day.
The prognostic implications of these mutations were highly subgroup-specific.
Interestingly, eobs for reads with 3% and 6% mutations were highly correlated with eobs from reads without mutations.
PIK3CA kinase mutations were highly clonal, more frequent in AR + vs.
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Rapid reliable diagnostics of DNA mutations are highly desirable in research and clinical assays.
She and other women with BRCA1 or 2 mutations are highly likely to develop breast cancer at some point in their lives.
We found that the ratio of deleterious to tolerated mutations was highly negatively correlated with the effective population size (Fig. 6c and Supplementary Fig. 10).
In particular, the distribution of mutations is highly associated with intrinsic molecular processes including transcription, chromatin organization, DNA replication timing, and DNA repair.
TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com