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Mutations were grouped according to country or geographic area, the latter including geographically and ethnically related countries with low mutation numbers.
In fact, when all samples with point mutations were grouped together, a significant association was found.
However, when samples with point mutations were grouped together, MLH1 expression was significantly decreased (p = 0.019; Figure 1D).
As all of these mutations were grouped to a particular area of the Drosophila third chromosome, the locus became known of as the bithorax complex (BX-C).
These dominant missense mutations were grouped into 5 classes, each of which resulted in a specific amino acid change (Table 1).
When a set of clonally related sequences was analyzed, all unique mutations were grouped together, since mutations that occurred multiple times were probably an indication of common ancestry rather than being mutations that occurred more than once.
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For example, A > C mutations are grouped with the complementary T > G mutations, A > G mutations are grouped with T > C mutations, and so on.
Mutations are grouped according to the TAF1 enrichment status (data from Rhee and Pugh, 2012 ) with the line colour depicting the mutator (AID*, red; sA3G*, black; EMS, blue).
Note that the mutations are grouped into different classes either affecting the quantity or function or a combination of both of the CFTR protein.
Therefore, CFTR mutations are grouped into 6 functional classes, so as to apply the same CFTR-corrective therapy within each functional class to drastically downscale the drug discovery pipeline (for reviews see Bell et al., 2015, Amaral and Farinha, 2013).
At the mean time, 92 patients who had no mutation were grouped as CADASIL-like patients.
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mutations were genotyped
mutations were used
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mutations were analyzed
mutations were verified
mutations were eliminated
mutations were inherited
mutations were made
mutations were confirmed
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