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DNMT3A mutations were frequently detected in FLT3 ITD mutated patients (P = 0.054, 0.071, and 0.071 in NSV, DMs, and R882 mutation, resp).
DNMT3A mutations were frequently detected in FLT3 ITD mutated NK AML patients but did not significantly affect clinical features and prognosis in Korean NK AML patients, and this issue needs to be further evaluated in the future.
G1613A and C1653T double mutations were frequently found in patients with HCC.
Mutations were frequently clustered and inherited in blocks hampering attempts to pinpoint individual causative mutations by genome analysis only.
Furthermore, PTEN mRNA expression was significantly downregulated in brain metastases compared with primary tumors, and PTEN mutations were frequently found in brain metastases.
In conclusion, we have demonstrated that mutations were frequently found in the embB gene, especially in EMB-resistant M. tuberculosis strains.
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CDC25C mutations are frequently found in FPD/AML and mutated CDC25C disrupts the G2/M checkpoint and promotes cell cycle progression.
p53 gene mutations are frequently identified in ovarian cancer tissue.
De-novo dominant mutations are frequently identified; somatic mosaicism and recessive disorders are also seen.
Ras mutations are frequently found in human cancers and play a fundamental role in tumorigenesis.
BRAF gene mutations are frequently seen in both inherited and somatic diseases.
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