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Exact(10)
We tested the hypothesis that these mutations were frequent in cancer genes, by studying again TP53.
As expected, homozygous mutations were frequent in six tumor suppressor genes (81%), with the exception of APC, while the five oncogenes also had a relatively high frequency of homozygous mutations (20%).
RUNX1 mutations were frequent in our series of CMML.
TET2 mutations were frequent in RAEB1 (7/16, 43.8%).
RAS pathway-activating mutations were frequent (38/79; 48.1%), which is in line with recent studies.
Fluoroquinolone resistance and associated gyrase mutations were frequent in various ribotypes, but no resistance to metronidazole or vancomycin was noted.
Similar(50)
Bödör, C. et al. EZH2 mutations are frequent and represent an early event in follicular lymphoma.
BRAF mutations are frequent in melanoma but their prognostic significance remains unclear.
p53 mutations are frequent in tobacco-related cancers and the mutation load is often higher in cancers from smokers than from nonsmokers.
(2015) demonstrate that passenger mutations are frequent in most genetically engineered congenic mice and persist even after extensive backcrossing.
These mutations are frequent in the mesenchymal class and characteristic of gemistocytic, sarcomatous, epithelioid, and giant cell histologies.
More suggestions(13)
variants were frequent
mutations were regularly
mutations were recurrent
mutations were often
deployment were frequent
mutations were repeated
mutations were likely
mutations were silent
mutations were dependent
mutations were missense
mutations were sequence-verified
mutations were heterozygous
mutations were rare
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