Sentence examples for mutations were firstly from inspiring English sources

Germline adenomatous polyposis coli (APC) mutations were firstly described in 1991 1, 2 as causing FAP with an autosomal dominant pattern of inheritance.

Complementary, EGFR mutations were firstly reported in lung cancer patients who had greater response to treatment with EGFR tyrosine kinase inhibitors.

BRCA1 mutations were firstly divided by position relative to amino acid 1365 (nucleotide 4213), because mutations 5' of this have been reported to exhibit markedly decreased AR transactivation ability [ 11].

The effect of these mutations was firstly to render the protein more stable in detergents used for crystallization and secondly to push the conformational equilibrium of the protein towards the antagonist bound state.

The BRCA2-8765delAG mutation was firstly described in breast cancer families from French-Canadian and Jewish-Yemenite populations; it was then reported as a founder mutation in Sardinian families.

Eleven prophages were firstly revealed.

The S81L pathogenic mutation has been firstly identified by Williams et al. (19).

Firstly, non-synonymous mutations were not randomly distributed in the repeats.

Further through protein structure analysis and site-directed mutation in CrGES, it was firstly demonstrated that among the high-conserved amino acid residues located in active pocket, Y436 and D501 with strong affinity to diphosphate function group, were critical for the dephosphorylation (the core step for geraniol formation).

Firstly, since the pedigrees and phenotypes of the mutation carrier were not available, whether the mutations were cosegregated with obesity individuals in China or not still remains unknown.

We further analysed mutation patterns when drug resistance was firstly detected in a given year of treatment.