Sentence examples for mutations were first from inspiring English sources

DNMT3A somatic mutations were first discovered by Yamashita and colleagues following sequencing of tissue from adult patients with de novo acute myeloid leukemia (AML) (Yamashita et al., 2010).

IDH mutations were first observed in human gliomas [ 102].

IDH1 and IDH2 mutations were first described in gliomas.

FBXW7/hCDC4 mutations were first identified in breast cancer and ovarian cell lines [ 14, 35].

Such mutations were first described in the Notch1 gene in T cell acute lymphoblastic leukaemia.

Homozygous PINK1 mutations were first described in three consanguineous families (Valente et al. 2004).

A recent study with regard to tumor vaccination showed a proof-of-concept in which somatic mutations are first detected using NGS.

Furthermore, the true prevalence of nondeletional mutations and Thailand type (− THAI) deletion mutation were first reported in this study.

In 2008, the R132H IDH1 mutation was first found in human glioblastoma multiforme [55].

To test this, the pdc2Δ519 mutation was first integrated by transformation and homologous recombination into the genome of the commercial EC1118 and the native Mab2C wine yeasts.

This process of evolution of activity by selection and mutation was first utilised ex vivo in phage display technology [2] and later using yeast or bacteria as vectors.