Sentence examples for mutations were discovered from inspiring English sources

Soon thereafter, the SDHC gene was found to be mutated in familial HNPGLs (PGL3; Niemann & Muller 2000) and SDHB mutations were discovered in familial PPGLs (PGL4; Astuti et al. 2001 b ).

Ten years ago, α-synuclein mutations were discovered as the first genetic cause of Parkinson's disease (PD).

(a) Somatic mutations were discovered in newly diagnosed RA patients and in one healthy (HC) by using the immunogene panel (presented on the left side), and exome sequencing (presented on the right side of the figure).

In two patients, the mutations were discovered in clones without CD45RA expression (effector-memory cells), and in one patient the mutated clone was CD45RA-positive (terminally differentiated effector-memory phenotype cells).

Further, the diagnosis of primary haemochromatosis has improved since various associated genetic mutations were discovered some years ago.

Some amino acid mutations were discovered to be crucial for virus virulence (Yang et al., 2014), but how they affect the viral virulence remained unclear.

But she added that many of the new inherited mutations being discovered so far are not "actionable". That means they aren't implicated in breast cancer, or it isn't clear how much they raise the risk of the disease and whether they warrant any change in treatment, Daly said.

As more Y chromosome mutations are discovered, he says, researchers will be able to paint an ever higher resolution picture of human prehistory--the when, where, and Y of human evolution.

Indeed, the three primary mutations are prerequisites for LHON, and many other rare LHON mutations are discovered continuously (c.f. http://www.mitomap.org/MITOMAP/MutationsLHON).

However, most pro-longevity mutations are discovered by systematic gene deletion or RNA interference screens, which mainly reveal abolished or diminished gene functions [ 1].

Although many somatic mutations are discovered, a small fraction of mutations promote cancer progress (driver genes that drive tumor evolution, about <1%) and majority of mutations are likely to be "passengers" which have no effects on tumor cell selection [ 3– 5].