Sentence examples for mutations were defined from inspiring English sources

Modules exhibiting a significantly greater number of mutations were defined as mutated modules (MM).

In contrast, "passenger mutations" were defined as essentially neutral and linked to the inherent genetic instability in cancer cells [34], [35].

De-novo mutations were defined as newly occurring changes (as compared to the first sequence time-point) within known epitopes or at HLA-association sites relevant for the host's HLA.

Mutations were defined according to International AIDS Society-USA Drug Resistance Mutation Group [ 15].

Noncoding mutations were defined as any mutation located outside of coding regions.

Benign mutations were defined as the combination of silent and LoFI mutations.

Therefore, the relative fitness of a cell with i driver gene mutations, j housekeeper gene mutations, k passenger mutations and l mutator gene mutations is defined as: (2) where is the proportion of tumour cells that have p, q, r and u driver, housekeeper, passenger and mutator mutations, respectively.

With one exception (patient 15, Supplementary Data 1), all class 1 mutations are defined as being somatic.

For every clone, a global effect of somatic mutations was defined by the sum of CADD scores.

These mutations are defined by their ability to promote or "drive" tumorigenesis and are therefore positively selected for in the development of cancer.

True mutations are defined as a change in a DNA sequence at a location other than the defining HVI∞ sequence characteristic of that sample.