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According to COSMIC database (Catalogue of Somatic Mutations in Cancer, Dec 2013) 1.4% of mutations are consequently not detected [ 6].
These data reflect that mutator mutations were selectively neutral, and consequently that mutator clones formed only after mutator mutations had hitchhiked to prominence on the back of clonal expansions driven by the selected driver mutations.
In the present study all patients with PIK3CA mutations were non-responders, and we were consequently unable to contribute to this aspect.
Four of her family members, 3 BC patients and a healthy individual were consequently also found to carry this mutation.
They were consequently torn.
Many were consequently struggling financially.
These were consequently used during revision sessions.
And there were consequently always fires there.
"They were consequently marginalized within the firm".
These were consequently rescored.
Further diagnostics were consequently performed.
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