Sentence examples for mutations were concentrated from inspiring English sources

With few variations among studies, stop mutations were concentrated almost exclusively in the periplasmic coding region of mucA (84 100%), in a proportion that was significantly higher than the few remaining stop mutations observed in the transmembrane (0 13%) (p<0.001, Z-test), and the cytoplasmic (0 3%) (p<0.001, Z-test) coding regions of mucA.

The mutations were concentrated in regions where CBX2 is predicted to be highly disordered and hydrophilic, and within these regions their distribution was relatively homogenous (Supplementary Figure S2).

The majority of the tRNA mutations were concentrated in the stem region that is under greater selective constraints than loop structures [ 58].

These mutations are concentrated in the fifth extracellular domain (exons 8 and 9), the juxtamembrane region (exon 11), and the kinase domain (exon 17) [6].

Most missense mutations are concentrated in the MBD and NID domains, disrupting the interaction with DNA and NCoR/SMRT, respectively (7).

Missense mutations are concentrated in the central part of p53, whereas nonsense, silent, and frameshift mutations are distributed throughout the coding region (Greenblatt et al. 1994).

Mutations are concentrated within the p53 DNA-binding domain of ∼200 amino acids, a domain that is central to the function of p53 as a transcription factor (Bullock and Fersht, 2001; Olivier et al, 2002; Tan et al, 2009).

These somatic mutations are concentrated in the CDRs and occur during DNA replication such that the progeny of a B cell produce antibody that is subtly different from that of the parent in terms of affinity for antigen.

The mutations varied from person to person but were concentrated in genes known to be involved in brain development.

The statistical associations of OAS1 mutations were not uniformly scattered throughout the entire gene but were concentrated in the upstream regulatory region, with twelve of the significantly associated mutations located in the OAS1 promoter and 5' untranslated region (UTR).

Afterwards, the fractions were concentrated.