Sentence examples for mutations were combined from inspiring English sources

Various mutations were combined to get a mutant containing as many IIAEK sequences as possible.

To further improve the activity, the F124W mutation and three previously reported beneficial mutations were combined randomly into double and triple mutants.

The most stabilising mutations were combined to make the thermostabilised mutants SAH6 (L99A + G278A + A505L) and SAH7 (L405A + P499A + A505L) that were more stable than SERT by 18 °C and 16 °C, respectively.

When both mutations were combined, even higher levels of ROS were detected.

Indeed, when these two mutations were combined (construct ANTXR2 153–154), ANTXR2 was fully converted into a receptor with the pore-inducing properties of ANTXR1 (Fig. 1B).

Neither deletion alone was sufficient to induce this phenotype: the phenotype was only observed when the mutations were combined and was observed in independently-derived strains, suggesting that this was not a spontaneous mutation elsewhere in the chromosome.

Here, the computational design of allosteric mutations was combined with in vitro and in vivo experiments to unravel nucleotide-responsive hot spots in the regulation of Hsp90.

We show here that when such mutations are combined they can have an additive effect on the stabilisation of the enzyme.

The more mutations are combined together, the more complex their mechanisms are.

Because the lineage defect is observed only when two homozygous mutations are combined, the phenotype is classified as "synthetic".

However, when scrib mutations are combined with Ras V12, the resulting cells not only overgrew but also became invasive.