Sentence examples for mutations were clustered from inspiring English sources
Blue-shifting mutations were distributed evenly along the retinal molecule while red-shifting mutations were clustered near the residue K257, which forms a covalent bond with retinal through a Schiff base linkage.
All these mutations were clustered at the junction of domains I and II of the E protein and it is likely that the epitope for mAb 503 is composed of at least E0-e, D0-a, and k strands of the E protein.
Mutations were clustered according to their relative z-scores in passages one and two (Figure 4).
Groups of SCD mutations were clustered in regions of protein exhibiting the highest degree of conservation between species.
Based on this protein domain structure, we then analyzed if the stop mutations were clustered at any particular region of mucA.
By contrast, double or triple mutations were clustered in the N- and C-terminal hotspots.
The tumour-suppressor gene TP53 is frequently mutated in breast tumours, and the majority of the mutations are clustered within the core domain, the region involved in DNA binding.
The many available crystal structures of RT reveal that, generally, in relation to their binding sites NRTI resistance mutations are generally more distally positioned, whilst for NNRTIs mutations are clustered.
Most of the pathologically important mutations are clustered in the catalytic core of this protein, hinting that altered GTPase and kinase activities may play a crucial role in pathogenesis5, 6. Targeting the LRRK2 signaling pathway is currently regarded as one of the most promising approaches in drug development for PD7,8,9,10.
Dominant KLHL3 mutations are clustered in short segments within the kelch propeller and BTB domains implicated in substrate and cullin binding, respectively.
In both genes, rapidly evolving sites and indel mutations are clustered in nonbinding domains, but the extent of rate acceleration in these domains is reduced relative to most previously characterized plant transcription factors.
