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Conclusion: The absence of mutations in these regions indicated that mutations were an unlikely cause of MGD or TS with Y mosaicism and suggested that there are others genes playing an important role in sex development.
PIK3CA mutations were an adverse prognostic factor for survival but not predictive for lapatinib benefit.
Robson et al. [ 20] found that BRCA1 mutations were an independent predictor of breast cancer mortality in univariable analysis.
Germline BRCA1 mutations were an independent predictor of breast cancer mortality in multivariate analysis (hazard ratio 2.4, 95% confidence interval 1.2 4.8; P = 0.01).
In a multivariate analysis, Helweg-Larsen and colleagues found that DHPS mutations were an independent predictor associated with increased death rates (20 ).
In the overall study population, and in patients in the paclitaxel plus placebo group, PIK3CA mutations were an adverse prognostic factor for survival, whereas in patients treated with paclitaxel plus lapatinib PIK3CA mutations were not significantly associated with OS outcome.
Similar(53)
Generation of mutations is an essential prerequisite for culture adaptation.
Drug resistance, acquired by mutations, is an obstacle to success.
Cisconfiguration of two mutations is an important element to consider.
P53 mutations are an adverse prognostic factor in esophageal cancer.
Mitochondrial DNA mutations are an important cause of neurological disease.
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