Sentence examples for mutations were accumulated from inspiring English sources

Interestingly in one case it was possible to construct a tree showing how founder mutations were accumulated.

More specifically, it was evaluated in each ensemble of networks modeled the average tendency in the fitness decay as mutations were accumulated successively in the networks, and epistatic coefficients of second, third, fourth and fifth order.

It is also interesting to note that the variability around average Log-scale fitness (indicated by blue bars) tended to increase as mutations were accumulated in the networks, suggesting a high probability for drastic epistatic fluctuations to be observed in the data.

The RHOA mutations were accumulated in amino-acid position 17.

Therefore, some fixed mutations were accumulated specifically in these populations.

Fearon et al. [37] suggested in 1990 that most CRCs arise from adenoma and that multiple gene mutations were accumulated during Carcinogenesis.

While much experimental effort is being devoted to the identification of the functional effects of individual mutations, mathematical modeling of tumor progression generally considers constant fitness increments as mutations are accumulated.

These data are consistent with the previous reports that mtDNA mutations are accumulated during aging process [ 25, 26].

In each clonal expansion, additional mutations are accumulated that drive cancer progression and lead to more invasive phenotypes.

According to the "vicious cycle" concept, mtDNA mutations are accumulated exponentially and should be associated with marked burst in ROS production [ 7].

When these mutations are accumulated to large extent in the cell genome the tumors are said to possess high-microsatellite instability (MSI-H) [ 15].