Sentence examples for mutations we set from inspiring English sources

Having demonstrated that we could correctly identify SNVs corresponding to known mutations, we set out to find the molecular lesion for let-504.

To investigate whether these transgenic flies can be used to efficiently produce site-specific mutations, we set out to knock-out ms(3 k81 using a previously designed gRNA (Yu et al. 2013).

For a low supply rate of beneficial mutations, we set τ=10000 generations, so that establishment and fixation of one beneficial mutation is likely to occur before a second positively selected site is introduced.

In order to determine the true frequency of detectable APC mutations, we set out to search exhaustively the entire coding region of APC for causative mutations in ten patients with classical FAP from Scottish kindreds shown to be linked to 5q markers.

Based on de novo mutations, we set the mutation rate, excluding CpG sites, in the human lineage (μH) to be from 0.44 × 10− to 0.56 × 10− per site per year, assuming the average generation time at 20 years (see Materials and Methods).

In order to better understand the pathogenic mechanism of the C134W mutation, we set out to characterize its molecular behavior.

To understand the functional features of this novel S59P mutation, we set out to compare it with two frequent mutations that are well known in the literature: the R92Q and T50M mutations [ 20- 231 31- 33, 38, 44, 45].

(2) Set of disease-related mutations: We obtained a set of amino acid substitutions in human proteins with disease-association.

To determine whether the 11 top-ranked features' set contributes to the prediction of driver mutations, we test independent set between DX-RF and Tan et al.'s method and construct four classifiers, called DX-SVMLight, DX-LibSVM, DX-RF, and mRMR-RF, respectively.

When we weakened one set of interactions by mutations we weakened the other set as well; there is cooperativity between the two interfaces.

To generate a database of somatic mutations, we took the complete set of 312 unique somatic mutations validated across the cases and joined them with COSMIC v54 database (Forbes et al., 2011).