Sentence examples for mutations we observed from inspiring English sources

In contrast, separating cases in single-mutated (n=60) or double-mutated/homozygous (n=21) RUNX1 mutations, we observed a non-significant trend towards a lower CEBPA expression in cases with double-mutated/homozygous mutations (mean±s.d. 126±89 vs 165±100; P=0.116).

Thus, in other patients, the CTL escape mutations we observed develop in OP177, which may have been transmitted, and persisted after transmission, suggesting a negligible fitness cost.

Furthermore, about one third of the mutations we observed were in E2, especially in HVR1, so the mutation rate of the HCV ORF outside E2 was just 0.59%.

Moreover, in human MFH (n = 8) lacking canonical RAS mutations, we observed nuclear staining of phospho-ERK by immunohistochemistry in greater than 30% of tumor cells in 7 of 8 samples (Fig. S2).

However, that the treated, control and Phase I groups (the latter group was infected for a median of 13 years) had very similar levels of private mutations at day 0 argues that the increased levels of mutations we observed in the treated populations over time were not due to higher overall levels of private mutations in later stages of infection.

In homozygous H1 infants bearing both the p-198A and int2-180A mutations, we observed a 4-fold decrease in the level of placental DC-SIGNR transcripts, disproportionately affecting the expression of membrane-bound isoforms compared to infant noncarriers (P = 0.011).

In addition to the two missense mutations, we observe also five synonymous variants.

For all three mutations we observe conservation scores close to 5.0, an indication that the positions are under evolutionary constraint.

It appears that most of the mtDNA missense mutations we observe become fixed in tumor progenitor cells without distinct physiological advantage.

The pattern of mutations we observe in these genes is consistent with selection to reduce the repression mediated by Rgt1 and Mth1.

Thus all of the mutations we observe can be explained by known oxidative products, but which of the possible products are most important in leading to the mutations is for the most part not known.