Sentence examples for mutations we next from inspiring English sources

In the absence of EGFR mutations, we next evaluated EGFR protein expression and phosphorylation status in LCSCs.

As PDR-1-CED-10 interaction was not affected by PDR-1 mutations, we next investigated whether the ubiquitylation capacity of PDR-1 was compromised by PDR-1 mutation.

Having determined the molecular consequences of gltA mutations, we next sought to use flux balance analysis (FBA) (Orth et al., 2010) to evaluate how changes in citrate synthase activity would affect cellular growth rates.

Based on the observation of the increased DSBs in senescent (operationally defined as >40 passage cells) MCF-7 cells overexpressing the PTEN ATP-binding mutations, we next examined the basal levels of ROS production in the five MCF-7 stable cell lines.

Because patients are heterozygous for both mutations, we next tested if the gain-of-function phenotype is also maintained when wild-type channels are coexpressed with the mutants by transfection of equal quantities of α1-subunit cDNAs; as evident from Figures 1 and 2 and Table 1, this was the case.

Jerez et al. recently reported an association between larger chromosome 5 deletions and TP53 mutations; therefore, we next examined the relationship between R72P genotype and TP53 DNA-binding domain mutation.

To assess whether our remaining pedigrees with FHHt and without WNK1/4 mutations had either CUL3 or KLHL3 mutations, we undertook NGS (next-generation sequencing) of these genes and also screened an alternative thiazide-sensitive sodium transporter (SLC4A8) hypothesized to be an additional candidate [ 14].

Having validated our ZFN expression vectors and mutation detection assay, we next tested each of the five ZFN pairs we made by OPEN in zebrafish embryos.

Having established that AA can contribute to somatic mutations in bladder cancer, we next examined the somatic mutation catalogs from a larger set of 347 bladder cancers for evidence of AA-induced mutations.

To analyze the dynamics of those mutations, we carried out high-depth next generation sequencing (NGS) to quantify the mutation allele frequencies at each time point of the disease course and to establish their modifications during leukemia progression.

As the hexamer mutations produced unexpected results, we next created two constructs where two or four uridines in the DSE were substituted by cytidines.