Sentence examples for mutations we estimated from inspiring English sources

To assess the functional potential of "nodal" synonymous mutations, we estimated codon bias.

Thus, from the effect of the single base mutations, we estimated the parameters ε ib.

To test for the presence of positive selection for preferred mutations, we estimated the log-likelihood of the data using a reduced model with γ = 0, denoted as NS (No Selection).

For heteroplasmic base substitution mutations, we estimated the frequencies of the mutant bases in the total mtDNA pool using the comparative peak height approach applied by a previous analysis of D. melanogaster MA line mtDNA divergence (Haag-Liautard et al. 2008).

Regarding the functional change of MRP2 caused by the ABCC2 rs12762549 (G>C) mutation, we estimated the odds ratio (OR) in subjects with mutated alleles of ABCC2 by changing the EC50 value when the in vivo transport activity of MRP2 from mutated ABCC2 was assumed to decrease to 10 90%.

To ensure the low frequency of adenine mutations was consistent with chemical mutagenesis rather than spontaneous mutation, we estimated the predicted level of spontaneous changes.

The mean age at last contact of G84E carriers without a prostate cancer diagnosis was 56.3.> Finally, to assess a potential founder effect for the G84E mutation, we estimated haplotypes based on the 15 genotyped SNPs in this region.

Based on the mutations' prevalence we estimated that three different tumor regions should be sampled to detect mutations in PBRM1, SETD2, BAP1, and/or KDM5C with 90% certainty.

Then the percentage reduction in breast cancers to be expected from administration of tamoxifen to subjects with these mutations is We estimated R+, R - and R twice, first using both the primary and secondary prevention trials, and second using the primary prevention trials only.

To evaluate how PSS depends on the relative mutation rate, we estimated the correlation between PSSs and relative mutation rates.

Under the assumption that both risks of developing a breast or an ovarian cancer are independent for mutation carriers, we estimated the hazard hbo(x) of developing either breast or ovarian cancer using the competing risks equation hbo(x) = hb(x)+ho(x).