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While the spectrum of BRCA1 mutations was varied in this group of 77 cancers, 57% of the mutations were Ashkenazi mutations (Additional file 5) reflecting the significant Jewish population in the communities served by the participating hospitals.
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Genomic deleterious mutation rate of females was 0.3 per generation whereas the male mutation rate was varied between 0.3, 0.6, 1.8 and 3.0 corresponding to α = 1, 2, 6 and 10.
The frequencies of the fixed mutation rates varied only slightly and the optimum mutation rate held constant when β was varied, although the mean effects of deleterious mutations changed substantially.
The sensitivity of the different imatinib-resistance mutations to treatment with dasatinib was varied.
(A ) Initial tumour size is fixed at 10 cells and mutation rate is varied.
In HFMOEA based optimization approach, the two parameters like crossover probability (PC) and mutation probability (PM) are varied dynamically through the output of a fuzzy logic controller.
On the other hand, it would make sense to study if mutation rates should be varied locally based on sequence conservation across the training set.
In this implementation, mutations are assumed to be clearly pathogenic (i.e. mutation testing is 100% specific) but mutation detection sensitivity can be varied.
(B – D ) Initial tumour size is varied and mutation rate is fixed at (B ) 10−6, (C ) 3.4 × 10−5, (D ) 10−3.
This was significantly lower than the somatic mutation rate in tumors, where non-silent somatic mutation rate had been estimated to be varied between 1 × 10−7 and 1 × 10−4 across different cancer types, with an average of 4 × 10−6.
The number of people affected by mitochondrial mutations is difficult to calculate, since resulting conditions are varied and have divergent symptoms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com