Sentence examples for mutations was supported from inspiring English sources

The importance of regulatory mutations was supported by our observation that each of the five distinct regulatory mutations was integral to the fitness of the isolates under Pi-limitation (fig. 3 A ). Hence, reordering of the regulatory network at the core of bacterial transcriptional control shown in figure 1 was essential in adapting to Pi-limitation.

The functional significance of these mutations is supported by the conserved nature of the amino acids across multiple species.

All the confirmed candidate mutations are supported by four or more capillary sequence reads.

The postulate that there could be an increased incidence of malignancy in persons with common HFE mutations is supported by some reports [ 6, 25, 47].

All these mutations were supported by high-quality Illumina sequence reads and gave no reason for suspecting artefactual data: no enrichment for being seen in sequences mapping to one strand and not particularly located at the ends of reads.

Nevertheless, these propositions on the roles of the T678S and M844L mutations are supported by the increased n-octane efflux by the T678A and M844A variants (Table  1), which have the side chains shortened to a methyl group.

Functional significance of the 4435A>G mutation was supported by the fact that ∼40 50% reduction in the levels of tRNAMet was observed in cells carrying the 4435A>G mutation.

The existence of this selection pressure operating independently of DNA methylation induced mutation is supported by our finding of mutational biases against CpG dinucleotides among RNA viruses in which conventional deamination and mutation as a consequence of methylation cannot occur.

The hypothesis of FGFR1 amplification as passenger mutation is supported by the observation that the prevalence of FGFR1 amplification does increase with tumour size (T1: 0%, T2: 13.7% T3: 16.7%).

The toxic potential of the mutation is supported by cell and animal models with anti-aggregant Tau (where the propensity for ß-structure is eliminated by insertion of prolines).

More importantly, out of the spots analyzed by mass spectrometry to determine protein identity, all but one (the metabolic enzyme METM) also showed consistent abundance changes in the second analysis, and so our conclusions about the set of proteins depleted in the dyf13 mutation are supported by this second analysis.