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If the number of viral mutations was sufficient (n≥3), comparisons of continuous outcomes between two groups were based on Mann-Whitney Rank Sum tests.
We found that introducing two mutations was sufficient to transform EGFP T65A, A206K) into a novel RSFP with improved properties when compared to rsEGFP.
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Together our data suggest that specific genome-instability mutations are sufficient to drive discrete mutational signatures, some of which share properties with mutation patterns seen in tumors.
Results indicated that although these five mutations are sufficient for tumor development, additional molecular lesions are required for invasive behavior.
Subsequent studies using the small- and larger-fruited NILs indicated that heterochronic regulatory mutations are sufficient for explaining allelic differences in fw2.2 [18].
In each case, a small number of designed mutations were sufficient to cause these domains to aggregate, and in two cases, to create bona fide prion activity.
In the present study, full sequencing of the optimized bacteriophage revealed that only two single nucleotide mutations are sufficient to improve its virulence towards a clinical strain.
The sequences of the derived dual specific antibodies demonstrate that a variety of limited mutations are sufficient for antibodies to recruit a second specificity.
Although some single point mutations are sufficient to render HIV resistant to individual drugs, escape from combination regimens requires accumulation of multiple mutations, which often appear in specific patterns.
While each of the PrP single point mutations is sufficient for neurodegeneration, the onset and duration of disease, the area of the brain affected and the pathology associated with neurodegeneration distinguish each of these diseases.
An intriguing question is whether these two mutations are sufficient to induce leukemia.
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