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One of these mutations was shown to increase the risk of heart attack by as much as 29%.
In some cases, the impact of mutations was shown to be additive.
The detailed frequency of the mutations was shown in Table 3.
Interestingly, this resistance, originating from the Asia-Africa mutations, was shown to be reversible by VP and similarly structured compounds.
Among these, the widely used Panc-1, which carries both KRAS and p53 mutations, was shown to form aggregates under appropriate culture conditions [ 6].
The detection rate of BRCA1 mutations was shown to increase from 10.8% (10/93) to 45.5% (10/22), thus allowing the minimization of the number of patients who should undergo BRCA1 mutation screening.
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The numbers of the mutated sequences and the mutations are shown below each bar graph.
Seven of the 13 patients with p53 mutations were shown to contain multiple mutated tissue samples.
The target sequence is shown in blue, and mutations are shown in red.
Copy-number losses are shown in blue, and mutations are shown in green.
The landscape of these PTPRS mutations is shown in Supplementary Fig. 3.
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CEO of Professional Science Editing for Scientists @ prosciediting.com