However, within a cancer type, the TH indices were correlated positively with tumor purity, while the correlation with the number of mutations was not always positive (Table S4).
Despite strong dominant attenuating effect, introduction of only two mutations was not sufficient for attenuating W1806 to the safety level acceptable for human use.
Unlike the UV radiation reversion of base-substitution mutations, the reversion of trp frameshift mutations was not enhanced in a uvrA umuC strain by photoreactivation after a post-UV-irradiation incubation.
Notably, while previous studies suggested a role of FUS in the repair of DSBs, the relative presence of DSB vs non-DSB damage caused by loss of FUS or FUS mutations was not known.
Other researchers were more cautious, saying that the genetics of rare mutations was not yet well enough understood to make conclusive statements about their effect on the behavior of specific genes.
Our data also demonstrated that the mechanism(s) inducing these mutations was not specific to one LTR-RT family over another.
The profile of the mutations was not the same in all three patients.
The presence of all three mutations was not related to higher Pfs25 QT-NASBA gametocyte prevalence or density during follow-up, compared to double mutant infections.
This was essentially true in all but one case, indicating that once the initial escape occurred, subsequent selection (e.g., acquisition of additional mutations for stronger escape or local compensatory mutations) was not the norm (Table S5).
In addition, because the association between CMS and DOK7 mutations was not known at the time of the design, this gene was not included in the microarray (Table 1).
In line with this, the number of parasite mutations was not related with the proportion of individuals in whom asexual parasites were still detectable on day 3, an indicator of parasite clearance time (PCT).
