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Exact(7)
p21 expression in cases with p53 gene mutations was low in six cases and high in one.
G>T tranversions were found in p53 and SMAD4, although the relative frequency compared to other mutations was low.
Fortunately, the prevalence of these mutations was low (<5%), which is in accordance with other studies [ 41, 42].
The overexpression of PI4KA in HCC could not be explained by HNF1A mutations: the frequency of these mutations was low in our HCC series (<4%) [ 28].
While the frequencies of KRAS and BRAF mutations were similar to frequencies usually described in primitive or other metastatic locations of NSCLC, the frequency of EGFR mutations was low.
The total proportion of mutations was low (25%), although the percentage of mutations in the BRCA1 and BRCA2 genes was higher, considering the breast and ovarian cancer families and the male breast cancer families respectively.
Similar(53)
However, according to the reports of EGFR-mutated TKI-resistant patients, the frequency of non-T790M secondary mutations is low.
Although the frequency of these mutations is low, we reasoned that their mutation might not be simply due to chance as none were observed to be mutated in colon or pancreatic tumors although the same genes were sequenced in similar numbers of tumors [17], [19].
In small populations, the efficiency of natural selection in removing deleterious mutations and promoting beneficial mutations is low [ 39].
This might be the case for other populations where the frequency of the CHEK2 founder mutations is low.
Frequencies of p53 mutations are low in primary MB but Increase significantly in recurrences, and mutant p53 proteins and Myc may collaborate to drive aggressive disease [ 8].
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