Sentence examples for mutations was initially from inspiring English sources

8, 15– 20 The validity of the pyrosequencing method for detecting KRAS and BRAF mutations was initially demonstrated using colon cancer cell lines and colon cancer tissues harboring KRAS and BRAF mutations.

The presence of kinase domain EGFR mutations was initially described in patients responding to gefitinib and erlotinib[ 9 11 ] and is now recognised as an important predictor of response, albeit without sufficient sensitivity or specificity to be used alone as a selection criterion for second line treatment.

Four other eat-6 mutations were initially isolated for feeble contractions and delayed relaxations of the pharyngeal muscles [9], and subsequently shown to affect the membrane potential of these cells [10].

Instead, all of these mutations were initially discovered because they affected other biological phenomenon, such as suppression of the zeste phenotype [Su z 2], dosage compensation (msl-3), or alteration of homeotic gene expression (Psc).

The two mutations were initially identified as de novo mutations.

Mutations were initially discovered in DKC1, located on the X chromosome (Heiss et al, 1998).

In some amplicons, certain mutations were initially not detected by the HRM assays.

FBXW7 mutations were initially identified by Spruck et al in ovarian and breast cancer cell lines.

Germline CDH1 mutations were initially reported in patients with hereditary diffuse gastric cancer (HDGC) (Guilford et al, 1998).

Germline mutations were initially identified in families with Li Fraumulticancerulticancer syndromes lacking the characteristic mutation in p53 (Bell et al, 1999).

Sequences were aligned and analyzed with ChromasPro 1.34 (Technelysium Pty Ltd), and nucleotide mutations were initially ascertained relative to the revised Cambridge Reference Sequence (rCRS) [ 79].