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Since, the expression of vitamin D receptor (VDR) in cells with Flt3 mutations was increased to the same extent as in other AML cells this suggests that failure of these cells to differentiate lies downstream of the receptor.
Thus, driver mutations accrued faster as the deleteriousness of housekeeper mutations was increased (Fig. 6D).
The frequency of mutations was increased for the DBD (Table 4 ) (P = 4.09 × 10−4) but not in the protein-binding domain (P = 0.37).
The substitution divergence (1.8 2.59%) exceeded two-three fold the estimates for single-copy loci and the fraction of transversional mutations was increased compared to the unique sequences (43% versus ~30%).
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If the effects of detrimental mutations are increased in the asexual-mutator populations, this will depress fitness gains.
Thus, the predicted consequence of FHM1, FHM2, and FHM3 mutations is increased levels of glutamate and potassium in the synaptic cleft (see also Fig. 2).
Compared with a previous profile score that was based on the log-odds likelihood calculation, the correlation between predicted and experimental ΔΔG of single-site mutations is increased in this approach from 0.33 to 0.68.
It was found that spontaneous mutations were increased several hundred fold when Mag expression was relatively high and Apn1 relatively low [12], [15].
It is still controversial whether mtDNA point mutations are increased in the Polg +/D257A mice.
The total of 26 missense mutations is increased compared to ten previously [ 2].
Another recent report [ 145] has shown that de novo copy number mutations are increased in sporadic SCZ.
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