Sentence examples for mutations was effective from inspiring English sources

Gefitinib as the first-line treatment for Korean patients with advanced pulmonary adenocarcinoma harboring EGFR mutations was effective and well tolerated.

Nevertheless, all but one of the mutations are effective GTPases and therefore do not significantly interfere with the conformational change and subsequent GTP hydrolysis associated with the decoding reaction.

Figure  1 shows that the LNA specifically designed for the GNAS/R201L mutation was effective to block the wild-type allele amplification.

It has been shown that vemurafenib that targets BRAF V600E) mutation is effective in treating melanoma but has limited success in treating colon cancer despite the same BRAF V600E) mutation.

All these lead us to conclude that the explicit use of the implicit hydrophobicity knowledge within the macro-mutation is effective.

The loss of function induced by the TGFBR2 mutation is effective in adventitial fibroblasts or in vascular SMCs for the non-Smad2/TGF-β1 pathway, but is overwhelmed in TAA-derived SMCs.

Although this method won't allow us to detect the exact gene in which the mutation resides for the highly conserved regions, the subsequent mutation validation showed it was effective in discerning real mutations from background in spite of gene copy number.

Thus, gefitinib chemotherapy in patients with advanced NSCLC harbouring EGFR mutations was highly effective.

Therefore, the initial chromosomal linkage of newly induced mutations is cost effective, because it reduces the number of crosses one needs to set up by 75%.

We observed that large drops in fitness during the MA experiment were associated with the accumulation of mutations in core genes, and so we sought to determine whether natural selection was effective against mutations in these genes.

Although therapeutic targeting of tumour-associated mutations may be effective in tumour management, most tumour mutations arise as later stage epiphenomena of tissue disorganisation and their involvement with tumour initiation, promotion, or progression has not been conclusively established (Sonnenschein and Soto, 1999, 2000; Seyfried, 2001; Bergstein, 2003).