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The list of validated hotspot mutations was dominated by transition changes at CpG dinucleotides (32/33, 97%).
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In small populations (e.g. in endemic island species), the dynamics of non-synonymous mutations is dominated by drift and the fixation probabilities of deleterious and advantageous mutations are expected to be approximately equal [5].
Relative to other cancer types, MOTs showed a similar somatic mutation density to breast, serous ovarian and pancreatic cancers, but a lower density than colorectal and stomach tumors [ 14, 15].> The mutation spectrum was dominated by C>T transitions, comprising 63.9 % of somatic substitutions, and this was common to all three tumor subtypes (Fig. 1b).
During the subsequent follow-up period of 54 112 months after transmission, sequence evolution in HIV-1 variants from all recipients was dominated by forward mutations (Ratio reversion/forward mutations R1: 4/14; R1: 13/39; R1: 23/56; R1: 7/27; R1: 2/29).
The mutation spectrum of the Marwari was dominated by C>T (G>A) transitions; a pattern which was also observed in the Icelandic, Norwegian Fjord, and Quarter horses.
Only during the last follow-up period (54 112 months after transmission) sequence evolution was dominated by forward mutations that mainly occurred in epitopes restricted by recipient HLA.
Instead, calcium sensitivity was dominated by the mutation effect (own, unpublished observations).
As Desai and Fisher showed, evolution in asexual budding yeast populations was dominated by the accumulation of multiple mutations of moderate effect [ 43].
Similarly, in our case, height was dominated by the effect of the FGFR3 mutation rather than by the XXY aneuploidy.
Tallahassee was dominated by sports.
Meadow East was dominated by Poa pratensis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com