Mutations were coupled to His at two sites in the interface, E124A and Y197C.
We now know that the random process of DNA mutation is coupled with the nonrandom process of natural selection.
Whereas the insertional mutation in our patient was coupled to valine on codon 129 of PRNP, it occurred on a methionine background in all previously reported patients.
A number of examples of single genes and mutations that have been coupled to behavioral variation are given, among them genes showing pleiotropic effects on pigmentation, and genes involved in regulation of the effects of neuropeptides.
Thirdly, ADAMTS-13 cleaves the von Willebrand factor involved in coagulation, and mutations in this protein are coupled to thrombotic thrombocytopenic purpura.
The fact that Ser237 and Arg276 appear together among CTX-M enzymes suggests they may work together to facilitate catalysis and, therefore, that the mutations at these positions may be coupled and nonadditive.
When a monogenic fiber mutation in the homozygous state is coupled with its homozygous WT counterpart, especially as NILs, an ideal model system is created for a comparative study of fiber development.
Mutations on RB1 are enriched at sample groups C and D, indicating that it is coupled to TP53 mutation status.
The biological parallel is a classical tumor suppressor model, one in which somatic mutation or methylation in one allele is coupled to loss of the other.
However, it is currently unclear whether this upregulation is coupled to TERT promoter mutations.
