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The GAG binding profile of the mutated full length chemokine (γ-m1, which includes these 9 mutations), was characterized.
Each of the non-antigenic mutations was characterized as beneficial (with probability εc) or deleterious (with probability 1 − εc), where εc << 1.
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This stems from the 'long-tail phenomenon' which states that cancer mutations are characterized by a small number of frequently mutated genes and a large number of infrequently mutated genes [ 18, 19].
Mycobacterium tuberculosis NHEJ proteins Ku and ligase D (LigD) were expressed in E. coli cells in the presence or absence of HR, and the Z-DNA-induced mutations were characterized.
The interstitial lung disease associated with the TERT mutations is characterized uniformly by dyspnea and a decreased diffusion capacity.
The brains of patients with progranulin mutations are characterized by nuclear and cytoplasmic inclusions that contain TDP-43 that is aberrantly cleaved, phosphorylated and ubiquitinated [11], [12].
Surprisingly, this analysis revealed that patients carrying B-RAF mutations had an impaired survival, whereas patients with N-RAS mutations were characterized by a favorable prognosis, each in comparison with the wildtype gene status.
Phenotypically, the asymptomatic heterozygous carriers of FMF mutations are characterized by the elevated levels of markers of inflammation such as CRP, SAA, and INF-γ [53], [54] and by specific glycosylation of AGP [55].
Mutations are characterized in Table 1.
The novel CYP11A1 mutations were characterized in vitro and in silico.
With this method, beneficial mutations are characterized as they arise in adapting populations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com