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The correlation between geographic distribution and KRAS mutations was available for 8,208 tests (99.7% of all performed tests).
Molecular testing for BRCA1 or BRCA2 mutations was available only on a research basis from 1994 until 2001, when NHS funding was provided to establish a laboratory service accessible to all high-risk families.
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Clinical annotation data, DNA copy number data, and somatically called mutations are available as Supplementary Data 1 3, respectively.
Presumably, different mutations were available in each population for natural selection to work on.
Over 10,000 mouse strains and more than 20,000 mouse ES cells containing gene-trapped or targeted mutations are available to researchers.
Several known mutations are available that drastically reduce or obliterate development of major structural traits, for instance.
Clinical characteristics of the families and description of the mutations were available upon request.
As a result, there are some protein kinases with the known WT crystal structure and known SNPs, yet no mutational models could be generated, because either all known mutations reside outside of the resolved crystal structure of the kinase catalytic domain or only synonymous mutations were available.
The spectrum of IDH1/IDH2 mutations is available elsewhere [ 24].
A list of these mutations is available from the bitbucket repository https://bitbucket.org/readbiomed/mutationtoolcomparison.org/readbiomed/mutationtoolcomparison
No mutations were available for a large number of genes uncovered by the Zfrp8 -interacting deficiencies.
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