Sentence examples for mutations was a from inspiring English sources

Among the somatic mutations was a loss-of-function mutation in TSC1 (tuberous sclerosis complex 1), a regulator of mTOR pathway activation.

The recent introduction of the CFTR potentiator ivacaftor into the therapy of a subgroup of patients with specific CFTR mutations was a major milestone and enormous stimulus for seeking effective ion transport modulators for all patients with CF. In this review, we discuss recent breakthroughs and setbacks with CFTR modulators designed to rescue mutant CFTR including the common mutation F508del.

We next wondered whether the G5-SSR426 capacity of biasing mutations was a determinant factor of the region at which most mutations were found.

One of these second-site mutations was a single bp transition, and the other was a 311 bp deletion.

The Cox proportional hazards model indicated that detecting EGFR mutations was a secondary prognostic factor (Table 4).

Chief among the refining mutations was a promoter mutation that activated expression of the dctA C4-dicarboxylate:H+ symporter gene (Quandt et al., 2014).

Japan's grotesque horror comedies, combining spurting prosthetic gore and computer-generated mutations, are a specialty of the New York Asian Film Festival.

But he suspects that the mutations are a laboratory artifact.

The result of these mutations is a reduced amount of phosphatidylcholine in bile.

Thus, the consequence of FHM2 mutations is a loss-of-function mechanism with non-functional proteins impairing pump function.

Presenilin mutations are a major risk factor for AD.