Exact(1)
This analysis clearly showed that there was no correlation between genotype severity (more deleterious mutations vs less destructive mutations) and clinical phenotype.
Similar(59)
The effect of V region mutations was less prominent, however, and again, the molecules were not recognized by anti-TCR Abs (results not shown).
Of the remaining 9 cc23 isolates (1 not fully characterized for ST and the remainder belonging to other less well-represented STs), another 2 harbored mutation XV, 6 harbored mutation V (16 ), and 1 harbored a previously unpublished deletion at nt T813 (designated mutation XVII).
SHM introduces missense mutations and (less frequently) deletions or insertions into the V regions of Igs.
By contraries, EGFR mutations were less frequently observed in tumours with solid component than those without solid component (34.2 vs 67.1%, P=0.001, odds ratio: 0.25, 95% confidence intervals: 0.11 0.61).
Mutations were less common in predicted base-paired regions (33% of all mutations) than in free-standing regions (67%).
Other mutations were less frequent.
EGFR mutations occur less frequently among Caucasians (10 15%) compared to East Asians (30 60%) (Lynch et al, 2004; Paez et al, 2004) in contrast to KRAS mutations for which the situation is opposite – Caucasians vs East Asians, 25 50% vs 5 15%, respectively (Mao et al, 2010; Roberts et al, 2010).
The other mutations were less frequently detected.
Neurexin-1-β mutations were less common.
The spectrum of disease-associated mutations includes frequent truncating mutations and less frequent missense mutations.
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