Sentence examples for mutations using both from inspiring English sources

By creating catalytically inactivating mutations using both multiplex and singleplex approaches the targets of DNMT1, DNMT3A, and DNMT3B were mapped with single-base pair resolution via whole-genome sodium bisulfite sequencing.

Among the eight tumors tested for mutations using both platforms, one tumor had a discordant result with Y373C mutation detected using OncoMap (iPLEX and hME) but the mutation, while detected in OncoScan, did not reach the frequency threshold for positivity.

Edited sequences were evaluated for DR mutations using both the Surveillance Drug Resistance Mutations (SDRM) list recommended by the World Health Organization [ 18], and the Stanford University Algorithm (http://hivdb.stanford.edu).edu

To determine whether DPY-21 influences dauer arrest generally as opposed to specifically in the context of eak-7 and akt-1 mutation, we determined the effect of reducing DPY-21 activity on dauer arrest in the background of other dauer-constitutive mutations using both dpy-21 RNAi and dpy-21 (null) genetic mutation.

Although few studies have investigated the impact of KRAS12 and KRAS13 mutations on CRC prognosis, a series of recent studies have highlighted the potential adverse prognostic impact of BRAF mutations, using both patients with stage II and III disease and patients across all disease stages (Ogino et al, 2009; Fariña-Sarasqueta et al, 2010).

We examined the common DNM2-S619L musingon using both in vitro and in vivo approaches.

19 This represents the largest study to date comparing the outcomes of clinical BRCA1/2 mutation analysis, using both Sanger sequencing and an assay for large genomic rearrangements.

After the initial analysis of mutations with known in vitro enzymatic activity, we further analyzed the novel mutations herein described using both models in parallel.

To gain additional information on the role of the IgH enhancer, we examined expression driven by enhancers that were merely weakened, rather than fully deleted, using both mutations and insulators to impair enhancer activity.

However, we did not detect any FUS mutations in Aus-12, using both Sanger sequencing and whole-exome sequencing.

To this end, we analyzed 23 colorectal cancers for P53 mutations and gene expression using both DNA and cDNA sequencing, real-time PCR and immunohistochemistry.