Sentence examples for mutations underlying human from inspiring English sources
Recent developments in genomic sequencing have advanced our understanding of the mutations underlying human malignancy.
Comprehensive knowledge on mutations underlying human cancers is essential for improved cancer diagnostics, personalised care and novel therapeutic interventions.
Additional genome wide screens through cancer cell DNA for somatic mutations ultimately will provide a more complete picture of the number and patterns of mutations underlying human oncogenesis.
With the plummeting costs of next generation sequencing technologies, sequencing of whole exomes and genomes is becoming a much more attractive method to identify rare, yet high risk, pathogenic mutations underlying human genetic disease.
It is important to distinguish between near-cognate and non-cognate mRNA:tRNA interactions, because such a definition may be important for informing therapeutic strategies for suppressing these two different categories of mutations underlying many human diseases.
To overcome these limitations, HDAM database is dedicated to collect and annotate mutations in nuclear genes underlying human diseases from published NGS studies.
The work is the fruit of the Innovative Genomics Initiative, a joint effort between UC Berkeley and UCSF that aims to correct DNA mutations that underlie human disease using CRISPR-Cas9, a pioneering technology co-developed by scientists at UC Berkeley that has made genome editing easier and more efficient than ever before.
NR2E1 hypomorphic mutations could underlie human cortical malformations.
The emergence of next-generation sequencing technology presents tremendous opportunities to accelerate the discovery of rare variants or mutations that underlie human genetic disorders.
Furthermore, whole-genome sequencing is just beginning to reveal what might be a multitude of rare, individual mutations that underlie human disease and other complex traits (Manolio et al., 2009).
Therefore, in combination with transgenics and conditional knockouts, ENU mutagenesis will continue to play an important role in the identification and characterization of mutations that underlie human neurological disease.
