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Patients harbouring these sensitizing mutations treated with EGFR TKI have derived significant clinical outcome when compared with standard platinum based chemotherapy doublets.
Additionally, 2/9 dogs with c-KIT mutations treated with surgery alone survived greater than 20 months.
Taken together, these two studies suggest that NSCLC patients with KRAS mutations treated with docetaxel alone may have particularly poor outcomes.
Neurologic improvement observed in patients with KCNJ11 mutations treated with SU manifests as improved motor function (11– 13) and, in some cases, ameliorated cognitive function (3, 14).
Dramatic response was also observed in several case reports of NSCLC patients harboring activating V600E BRAF mutations treated with vemurafenib, another inhibitor of BRAF kinase [ 86– 86].
Clinical studies of women with BRCA1 mutations treated with radiation for breast cancer have not demonstrated increased acute or late toxicity (Pierce, 2005).
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a, P < 0.01 compared with GFP only control; b, P < 0.01 compared with corresponding gene transfection without BMP7 treatment; c, P < 0.01 compared with GFP control treated with BMP7; and d, P < 0.01 compared with BMPRII mutation treated with BMP7.
Macrophages with TRIF mutation treated with poly (I∶C) showed abolishment of MAP kinase ERK activation [32] and all MAP kinases showed similar kinetics in wildtype and TRAF6 KO [11].
Gellermann et al. [ 8] reported three children with FSGS associated with WT1 mutation treated with combined CsA and prednisone therapy given for 6 and 12 months.
Tooth discoloration was identified in five patients, representing ∼7.5% of the 67 subjects with a KCNJ11 mutation treated with sulfonylureas in the two centers.
In LUX-Lung 6, the median OS in patients with Del19 EGFR mutation treated with afatinib versus chemotherapy was 31.4 versus 18.4 months (P = 0.0229).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com