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This pattern may be driven by the relatively large mutational target size of degenerative mutations to this locus and the apparent lack of associated pleiotropic effects.
Mutations to this nerve network can cause deafness.
Mutations to this gene determine whether a patient will respond to the drug Iressa.
Mutations to this part of Munc13 affected the ability of the calcium channels to open and close.
Several mutations to this conserved surface disrupted TRIP13 binding in a yeast two-hybrid assay, while retaining MAD2 binding.
However, the exact contribution of different cell types and oncogenic mutations to this heterogeneity are not well understood.
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Introduction of a 3-bp substitution mutation to this core sequence (from CTTCCTCA to CTTgtaCA) completely abolished ATF4 activation (Fig. 7D).
Author response: Yes, I agree that it would be possible in principle to add mutation to this.
We concluded that WDR36 plays an important functional role in the retina homeostasis and mutation to this gene can cause devastating retinal damage.
In A. thaliana, mutation to this key domain results in the loss of ABA2 function in the aba2-13 mutant (González-Guzmán et al. 2002).
As a result of this process, mutations to the DNA sequence are now incorporated into one strand.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com