Sentence examples for mutations to study from inspiring English sources

However, there is no proven technology that allows the generation of targeted mtDNA mutations to study the basic characteristics of mitochondrial biogenesis.

This is done both in the absence of mutations (to study cancer development and treatment without resistance) and in the presence of mutations (to study cancer development and treatment in the face of emerging resistant mutants).

Using rolling mutations to study TRP2, we found that a specific six base TRP2 motif is essential for binding nuclear extract proteins (Figure 2).

Therefore, we and others have generated murine haemophilia B models with human F9 mutations to study the immunogenicity of hFIX protein [ 10, 12, 20].

Visco advocated a direct research program to examine treatment options for women who test positive for deleterious BRCA mutations, to study what counseling is necessary and how to avoid discrimination in health insurance and employment.

The detailed description of the allosterically regulated enzymes, such as glucose-6 phosphate dehydrogenase (G6PD), pyruvate kinase (PK), and phosphofructokinase (PFK) enabled the direct application of causal SNP mutations to study well-known genetic and environmental variations.

The murine Guca1a and Guca1b genes, encoding GCAP1 and 2 respectively, are in a tail-to-tail array on chromosome 17, and this provided a simple strategy via a double knock-out mutation, to study the impact of a complete loss of GCAP function in the mouse [17].

For instance, our lab has recently successfully used phosphomimetic mutation to study the activation of SCAR.

In addition, we monitored the vibrations of NO3–, which was substituted for Cl–, and examined the effect of the D2-K317R mutotion to study the interaction of NO3– in the Cl-1 site.

To date, these projects have resulted in 29 primary research publications [ 25], ranging from reports on the cumulative risk of breast cancer in families with BRCA1 and BRCA2 mutations to studies of psychological morbidity in these families [ 8, 19, 26- 37].

For instance, this technique was applied to isolate strains with spontaneous [8], [18], [19] or chemically induced [20] mutations leading to heritable eye mutations and to study acute toxic effects on the eye [18].