Sentence examples for mutations to predict from inspiring English sources

Furthermore, Drugscore-PPI was used for computational alanine-scanning of a dataset of 18 targets with a total of 309 mutations to predict changes in the binding free energy upon mutations in the interface.

In contrast, others reported TP53 mutations to predict sensitivity to a dose-dense epirubicin-cyclophosphamide regimen [16].

CRC specimens (Table 1) were derived from the following sources: Group A (n = 135) included material from patients with metastatic CRC that was prospectively investigated for KRAS codon 12 and 13 mutations to predict patient eligibility for treatment with anti-EGFR antibodies, according to current guidelines [5], [6].

These findings emphasize the importance of investigating PRNP polymorphisms or mutations to predict disease occurrence.

Recently, Hofree et al. reported a network-based stratification approach that can use somatic mutations to predict cancer subtypes [ 15].

It seems that the most difficult mutations to predict are either located in coil and exposed residues or those which cause only small stability changes (within the range of −1 and 1 kcal mol − 1).

From identifying IDH1 mutations to predicting radiation response, mathematical modeling has already demonstrated a potential for clinical effectiveness.

Similar to what has been recorded by others [4], we found TP53 mutations not to predict resistance to paclitaxel treatment.

These studies clearly suggest that PI3KCA mutations seem to predict cell response to rapalogs.

In silico mutation evaluation to predict protein structure, was conducted using two programmes: Mutation taster [8] and PolyPhen-2 [9].

For example, in most cases, the influence of a novel fetal mutation is hard to predict.