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Specific mutations to particular ethnic groups have been described.
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Passenger mutations specific to particular mouse strains can distort experimental outcomes.
These constraints might preserve certain mutations specific to particular subgroups within the informational ortholog groups.
A knowledge of the critical mutations conferring resistance to particular drugs is important in understanding modes of drug action and mechanisms of resistances.
People sometimes argue that linking particular mutations to ethnic groups stigmatizes the groups, Dr. Offit said.
This suggests that there is no selection for particular mutations to clonally expand.
In particular, mutations to one of several residues in FI (Q40, D45, L77, and K97) were shown to eliminate activation of the poly(ADP-ribosyl)ation activity of PARP-1 in the presence of DNA, despite the fact that these mutants could still bind DNA with an affinity similar to that of the wild-type enzyme.
The interplay between transcription and mutational processes can lead to particular mutation patterns in transcribed regions of the genome.
However, detecting compound heterozygotes between ΔF508, the most common disease causing mutation, and other mutations which are rare is difficult as some mutations are common only to particular ethnic groups.
Different modes of natural selection, however, can cause the frequencies of particular nonsynonymous mutations to increase within a population [ 54].
Another example is that doctors treating patients with H.I.V. or AIDS often test a patient's virus for mutations that induce resistance to particular drugs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com