Sentence examples for mutations to one from inspiring English sources

These controls consist of a mixture of oligonucleotides (100 to 120 bases long) each designed for the detection of one or more disease-causing mutation(s), depending on the proximity of the mutations to one another.

He and his colleagues discovered that some neurons in the overgrown hemisphere have mutations to one gene.

Here we show that by using targeted sequencing of multiple samples, we can reduce the number of candidate causative mutations to one or two per line.

This is because some synonymous mutations to one ORF are nonsynonymous to the other ORF and hence have been removed by purifying selection, causing overestimation of ω1 and ω2.

The formalism we propose here sets a general framework for the study of the impact of mutational mechanisms on genome length with two important features: (i) genomes can undergo both small indels and large chromosomal rearrangements and (ii) genomes undergo a size-dependent number of mutations rather than limiting the mutations to one per replication.

In particular, mutations to one of several residues in FI (Q40, D45, L77, and K97) were shown to eliminate activation of the poly(ADP-ribosyl)ation activity of PARP-1 in the presence of DNA, despite the fact that these mutants could still bind DNA with an affinity similar to that of the wild-type enzyme.

In each replicate, we assigned a mutation to one founder and simulated the genotypes of other individuals generation by generation.

Specifically, in each replicate, we assigned a mutation to one founder and then simulated the genotypes of all other individuals according to Mendelian inheritance rules.

Approximately 30%% of all human cancers contain a mutation to one of the ras oncogenes (Ki- ras, Ha- ras, N- ras) that causes the resulting protein to be constitutively active [ 13].

As pointed out long ago (Miyata and Yasunaga 1978), this approach is problematic, because a synonymous mutation to one of the overlapping genes may be nonsynonymous to the other gene and thus may be non-neutral.

Activation of an oncogene requires only a single mutation to one of the two homologous alleles of a proto-oncogene; the remaining intact allele cannot compensate for the resulting dominant oncogenic defect.