Sentence examples for mutations to modify from inspiring English sources

Deacon's idea of relaxed selection, he says, "allows mutations to modify certain genes and inactivate others so they don't have such a specific function".

These oligonucleotides are designed to repair genetic mutations, to modify genomic sequences in order to compensate for gene deletions, or to modify RNA processing in order to ameliorate the effects of the underlying gene mutation.

Oligonucleotides can be designed to repair genetic mutations, to modify genomic sequences in order to compensate for gene deletions, or to modify RNA processing in order to improve the effects of the underlying gene mutation.

Trapping of mixed disulphides is facilitated by cysteine to alanine mutation to modify the CXXC motif to CXXA.

Interestingly, these mutations are suggested to modify the severity of the HCM phenotype but not cause it per se.

However, we did not observe any obvious modification of the E2F1-dsRNA phenotypes (data not shown), indicating that these particular Su z 2 point mutations are insufficient to modify these phenotypes.

As outlined in Figure 3A, the N758Y mutation was predicted to directly abolish the interaction with substrate, whereas the Y750W mutation was designed to modify the outer rim of the substrate-binding cleft.

The study by Ciani and colleagues showed that the M404V mutation is able to modify the secondary structure of the domain and affects its ability to bind to Lys-linked multiubiquitin chains in vitro [ 11].

Evolvability has been defined as a compromise between robustness against single mutations and the capability to modify the functional response upon increasing mutational pressure.

Our results are consistent with the idea that normal FGFR3 signal transduction in SrAp cells is altered by the p.gly380arg mutation, leading to modified stem-cell self-renewal patterns that confer a proliferative advantage compared with adjacent non-mutant cells.

For example, Fc gamma receptor, Toll like receptor or mannose binding protein mutations have been shown to modify the detection of pathogens leading to pneumococcal severe infections, Gram-negative bacteria septic shock, and meningococcal disease, respectively.